(S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide → HCID 67009368, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(pyrimidin-5-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 250, (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(pyrimidin-5-yl)acetamido)propanamide. 1H-NMR (400 MHz, CDCl3): σ 9.17 (s, 1H), 8.72 (s, 1H), 8.36 (s, 1H), 7.42-7.21 (m, 7H), 7.06-6.91 (m, 5H), 6.68 (d, 1H), 4.70-4.63 (m, 3H), 4.57 (d, 1H), 3.98 (dd, 1H), 3.60-3.54 (m, 3H). MS (EI) for C28H25FN4O4. found 501.2 (MH+).

Provenance & Evidence