1,2,4-Triazole-1-acetic acid → HCID 46191472, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(1H-1,2,4-triazol-1-yl)acetic acid and (2S,4R)—N-(4-(4-fluorophenoxy)phenyl)-4-(3-methylbenzyl)pyrrolidine-2-carboxamide, gave Compound 171, (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)-4-(3-methylbenzyl)pyrrolidine-2-carboxamide. Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 10.00 (s, 1H), 8.43 (s, 1H), 7.95 (s, 1H), 7.55 (d, 2H), 7.23-7.15 (m, 3H), 7.08-6.91 (m, 8H), 5.23 (q, 2H), 4.53-4.48 (m, 1H), 3.83-3.76 (m, 1H), 2.73-2.61 (m, 4H), 2.29 (s, 3H), 2.00-1.89 (m, 2H). MS (EI) for C29H28FN5O3. found 514.2 (MH+).

Provenance & Evidence