Sodium Thiosulfate → HCID 86696534, compound

Participants

Reaction Steps

The formula (9) compound: 2-[2-(1-hydroxycyclohexyl)-1-ethyn-1-yl]-N9-propargyladenine (200 mg, 0.67 mmol) was dissolved in dimethylformamide (7 mL), and N-chlorosuccinimide (180 mg, 1.3 mmol) and potassium acetate (20 mg, 0.20 mmol) was added thereto, and the mixture was stirred for 28.5 hours. A saturated sodium thiosulfate aqueous solution was added thereto to stop the reaction, and then the mixture was extracted with chloroform, and the organic layer was dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure, the residue was suspended in chloroform, and the solid was collected by filtration to give the product of interest (49 mg, 0.15 mmol, 22%).

Provenance & Evidence