5-(Tributylstannyl)-1,3-thiazole → HCID 71577058, compound

Participants

Reaction Steps

N2-(4-Methoxy-6-(thiazol-5-yl)pyridin-3-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine was prepared by the procedure described in Example 7, using N2-(6-chloro-4-methoxypyridin-3-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine and 5-(tributylstannyl)thiazole. LCMS (10 cm_ESCI_Formic_MeCN): [MH+]=383 at 2.60 min. 1H NMR δ (ppm) (CDCl3): 9.65 (1H, s), 8.9 (1H, d, J=2.1), 8.2 (1H, d, J=1.1), 8.1 (1H, d, J=2.1), 7.75 (1H, s), 7.55 (1H, s), 5.27 (1H, s), 4.1 (3H, s), 3.2 (3H, d, J=4.7).

Provenance & Evidence