Ethanol → HCID 58379645, compound

Participants

Reaction Steps

A mixture of compound 46 (8.2 g, 15 mmol) and lithium hydroxide (480 mg, 20 mmol) in 2:1 ethanol:water (150 mL) was heated to 75° C. resulting in a solution. After 2 hours, the solution was cooled to room temperature and concentrated. The residue was taken up in water (200 mL) and the solution was acidified with 1 N HCl (20 mL). The precipitate was collected by filtration and dried at 60° C. under vacuum to afford 4-({1-[(benzyloxy)carbonyl]piperidin-4-yl}amino)-6-quinolin-3-yl-1,5-naphthyridine-3-carboxylic acid (compound 47) (7.8 g, 98%).

Provenance & Evidence