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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1630363Generated: November 3, 2026

Dimethyl Sulfoxide → 1-(2-Ethoxyethyl)-4-(2-methyl-4-nitrophenyl)piperazine

https://huagongshe.com/reaction/1630363

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethyl SulfoxideHCID 679—
Reactantp-FluoronitrobenzeneHCID 9590—
Reactant1-(2-Ethoxyethyl)piperazineHCID 2734643—
Product1-(2-Ethoxyethyl)-4-(2-methyl-4-nitrophenyl)piperazineHCID 67171755—

Reaction Steps

In the same manner as in Production Example 5-1, but using 4-(2-ethoxyethyl)piperazine in place of N-ethylpiperazine used in Production Example 5-1, using 4-nitrofluorobenzene in place of 2-fluoro-5-nitrobenzyl alcohol, and using dimethylsulfoxide in place of N-methylpyrrolidone, 1.50 g of the entitled compound was obtained as a yellow solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08791125B2
Source datasetuspto-grants-2014_07
ORD IDord-8f44a86726af4711855fc2235fe8e5fd
Source noteuspto-grants-2014_07