HCID 43461608, compound → HCID 86616127, compound

HRID 1630397Notes

Reaction equation

HRID 1630397 reaction equation
[CH2:1]([N:4]1[C:12](=[O:13])[C:11]2[C:6](=[N:7][C:8](SC)=[N:9][CH:10]=2)[N:5]1[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][C:23]([OH:26])([CH3:25])[CH3:24])[N:17]=1)[CH:2]=[CH2:3].[NH2:27][C:28]1[CH:33]=[CH:32][C:31]([N:34]2[CH2:39][CH2:38][N:37]([CH2:40][C:41]([N:43]([CH3:45])[CH3:44])=[O:42])[CH2:36][CH2:35]2)=[CH:30][CH:29]=1>>[OH:26][C:23]([CH3:25])([CH3:24])[CH2:22][C:18]1[N:17]=[C:16]([N:5]2[C:6]3=[N:7][C:8]([NH:27][C:28]4[CH:33]=[CH:32][C:31]([N:34]5[CH2:39][CH2:38][N:37]([CH2:40][C:41]([N:43]([CH3:45])[CH3:44])=[O:42])[CH2:36][CH2:35]5)=[CH:30][CH:29]=4)=[N:9][CH:10]=[C:11]3[C:12](=[O:13])[N:4]2[CH2:1][C:2]#[CH:3])[CH:21]=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 43461608HCID 43461608, compoundHCID 67171653HCID 67171653, compound

Product 1

HCID 86616127HCID 86616127, compound

Procedure

27 mg of the entitled compound was obtained as a yellow solid in the same manner as in Example 113-1 to 113-2, for which, however, 2-allyl-1-[6-(2-hydroxy-2-methylpropyl)pyridin-2-yl]-6-(methylthio)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one obtained in Example 81-2 was used in place of 2-allyl-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-(methylthio)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one used in Example 113-1, and 2-[4-(4-aminophenyl)piperazin-1-yl]-N,N-dimethylacetamide was used in place of 4-(4-methylpiperazin-1-yl)aniline used in Example 113-2.

Sources & evidence

ORD record
ord-a4d167fe0d1649db9a7bedad04593070
Source dataset
uspto-grants-2014_07
Patent number
US08791125B2

Reaction notes

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