HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimedone → 4-{(E)-2-[5-(3-Fluorophenyl)pyridin-2-yl]vinyl}-7,7-dimethyl-5-oxo-4,5,6,7,8,9-hexahydro-1H-pyrazolo[3,4-b]quinoline 3-cyclopropylmethylcarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimedone | HCID 31358 | — |
| Reactant | (E)-3-[5-(3-Fluorophenyl)pyridin-2-yl]propenal | HCID 86676729 | — |
| Reactant | 5-Amino-1H-pyrazole 3-cyclopropylmethylcarboxamide | HCID 131731700 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-{(E)-2-[5-(3-Fluorophenyl)pyridin-2-yl]vinyl}-7,7-dimethyl-5-oxo-4,5,6,7,8,9-hexahydro-1H-pyrazolo[3,4-b]quinoline 3-cyclopropylmethylcarboxamide | HCID 137195792 | — |
Reaction Steps
According to general procedure A, a mixture of 50 mg of (E)-3-[5-(3-fluorophenyl)pyridin-2-yl]propenal, 40 mg of 5-amino-1H-pyrazole-3-cyclopropylmethylcarboxamide, 31 mg of dimedone and 5 ml of ethanol is boiled under reflux for 2 hours. After cooling, the mixture is concentrated and purified by column chromatography (silica gel, methanol:DCM=5:95).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08791133B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-0c7f95533d2a4440bdf1247e41b6a23c |
| Source note | uspto-grants-2014_07 |