HRID1630412

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID566106

5-Isopropyl-1,3-cyclohexanedione

C9H14O2

HCID86676729

未命名化合物

HCID131731700

未命名化合物

PRODUCTS

生成物

结构：CC(C)C1CC(=O)C2=C(C1)Nc1[nH]ncc1C2/C=C/c1ccc(-c2cccc(F)c2)cn1.NC(=O)CC1CC1

HCID137195796

未命名化合物

PROCEDURE

实验过程

The title compound is prepared as a mixture of diastereomers according to procedure A from 50 mg of (E)-3-[5-(3-fluorophenyl)pyridin-2-yl]propenal, 34 mg of 5-isopropylcyclohexane-1,3-dione and 40 mg of 5-amino-1H-pyrazole-3-cyclo-propylmethylcarboxamide.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4f83387cf10c4623ade7e590d58a0440
来源数据集: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08791133B2
来源说明: uspto-grants-2014_07

反应 SMILES

[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[CH:10][C:11](/[CH:14]=[CH:15]/[CH:16]=O)=[N:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1.[CH:18]([CH:21]1[CH2:26][C:25](=O)[CH2:24][C:23](=[O:28])[CH2:22]1)([CH3:20])[CH3:19].[NH2:29][C:30]1[NH:34][N:33]=[CH:32][CH:31]=1.[CH2:35]1[CH:37]([CH2:38][C:39]([NH2:41])=[O:40])[CH2:36]1>>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[CH:10][C:11](/[CH:14]=[CH:15]/[CH:16]3[C:24]4[C:23](=[O:28])[CH2:22][CH:21]([CH:18]([CH3:19])[CH3:20])[CH2:26][C:25]=4[NH:29][C:30]4[NH:34][N:33]=[CH:32][C:31]3=4)=[N:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1.[CH2:36]1[CH:37]([CH2:38][C:39]([NH2:41])=[O:40])[CH2:35]1