Dimedone → HCID 178426733, compound

HRID 1630415Notes

Reaction equation

HRID 1630415 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[CH:10][C:11](/[CH:14]=[CH:15]/[CH:16]=O)=[N:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1.[CH3:18][C:19]1([CH3:27])[CH2:26][C:24](=O)[CH2:23][C:21](=[O:22])[CH2:20]1.[NH2:28][C:29]1[NH:33][N:32]=[C:31]([C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])[CH:30]=1>>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[CH:10][C:11](/[CH:14]=[CH:15]/[CH:16]3[C:23]4[C:21](=[O:22])[CH2:20][C:19]([CH3:18])([CH3:27])[CH2:26][C:24]=4[NH:28][C:29]4[NH:33][N:32]=[C:31]([C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])[C:30]3=4)=[N:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 31358DimedoneHCID 86676729(E)-3-[5-(3-Fluorophenyl)pyridin-2-yl]propenalHCID 178450747HCID 178450747, compound

Product 1

HCID 178426733HCID 178426733, compound

Procedure

The title compound is prepared according to procedure A from 620 mg of (E)-3-[5-(3-fluorophenyl)pyridin-2-yl]propenal, 383 mg of dimedone and 500 mg of tert-butyl 5-amino-1H-pyrazole-3-carboxylate.

Sources & evidence

ORD record
ord-7ceb321804094ee49a88c450c0e4c99a
Source dataset
uspto-grants-2014_07
Patent number
US08791133B2

Reaction notes

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