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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1630419Generated: October 26, 2026

Dimedone → 4-[(E)-2-(5-Bromopyridin-2-yl)vinyl]-7,7-dimethyl-5-oxo-4,5,6,7,8,9-hexahydro-1H-pyrazolo[3,4-b]quinoline 3-cyclopropylmethylcarboxamide

https://huagongshe.com/reaction/1630419

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimedoneHCID 31358—
Reactant3-(5-Bromopyridin-2-yl)prop-2-enalHCID 86676730—
Reactant5-amino-1H-pyrazole 3-cyclopropyl methylcarboxamideHCID 131731709—
Product4-[(E)-2-(5-Bromopyridin-2-yl)vinyl]-7,7-dimethyl-5-oxo-4,5,6,7,8,9-hexahydro-1H-pyrazolo[3,4-b]quinoline 3-cyclopropylmethylcarboxamideHCID 137195800—

Reaction Steps

The title compound is prepared analogously to procedure A from 150 mg of (E)-3-(5-bromopyridin-2-yl)propenal, 100 mg of dimedone and 127 mg of 5-amino-1H-pyrazole-3-cyclopropyl methylcarboxamide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08791133B2
Source datasetuspto-grants-2014_07
ORD IDord-61630322f84d4471b97bc6945497a243
Source noteuspto-grants-2014_07