Potassium Phosphate, Tribasic → 4-{(E)-2-[5-(3,4-Difluorophenyl)pyridin-2-yl]vinyl}-7,7-dimethyl-5-oxo-4,5,6,7,8,9-hexahydro-1H-pyrazolo[3,4-b]quinoline 3-cyclopropylmethylcarboxamide

Participants

Role	Name	HCID	Charge
Reactant	Potassium Phosphate, Tribasic	HCID 62657	—
Reactant	3,4-Difluorobenzeneboronic acid	HCID 2734337	—
Reactant	4-[(E)-2-(5-Bromopyridin-2-yl)vinyl]-7,7-dimethyl-5-oxo-4,5,6,7,8,9-hexahydro-1H-pyrazolo[3,4-b]quinoline 3-cyclopropylmethylcarboxamide	HCID 137195800	—
Catalyst	Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)	HCID 178418228	—
Product	4-{(E)-2-[5-(3,4-Difluorophenyl)pyridin-2-yl]vinyl}-7,7-dimethyl-5-oxo-4,5,6,7,8,9-hexahydro-1H-pyrazolo[3,4-b]quinoline 3-cyclopropylmethylcarboxamide	HCID 137195802	—

Reaction Steps

The title compound is prepared according to procedure C from 125 mg of 4-[(E)-2-(5-bromopyridin-2-yl)vinyl]-7,7-dimethyl-5-oxo-4,5,6,7,8,9-hexahydro-1H-pyrazolo[3,4-b]quinoline-3-cyclopropylmethylcarboxamide, 60 mg of 3,4-difluorophenylboronic acid, 134 mg of K3PO4 and 37 mg of 1,1′-bis(diphenylphosphino)ferrocenepalladium dichloride.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08791133B2
Source dataset	uspto-grants-2014_07
ORD ID	ord-273e0180e1094852985fd8f418249347
Source note	uspto-grants-2014_07