3-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one → 3-[4-(3-Amino-oxetan-3-yl)-phenyl]-8-bromo-2-phenyl-chromen-4-one

HRID 163055Notes

Reaction equation

HRID 163055 reaction equation
[Br:30][c:31]1[cH:32][cH:33][cH:34][c:35]2[c:36](=[O:64])[c:37](-[c:47]3[cH:48][cH:49][c:50]([C:53]4([NH:57][S:58]([C:59]([CH3:60])([CH3:61])[CH3:62])=[O:63])[CH2:54][O:55][CH2:56]4)[cH:51][cH:52]3)[c:38](-[c:41]3[cH:42][cH:43][cH:44][cH:45][cH:46]3)[o:39][c:40]12.[NH2:1][C:2]1([c:3]2[cH:4][cH:5][c:6](-[c:7]3[c:8](=[O:9])[c:10]4[c:11]([cH:12][cH:13][c:14]([F:15])[cH:16]4)[o:17][c:18]3-[c:19]3[cH:20][cH:21][cH:22][cH:23][cH:24]3)[cH:25][cH:26]2)[CH2:27][CH2:28][CH2:29]1>>[Br:30][c:31]1[cH:32][cH:33][cH:34][c:35]2[c:36](=[O:64])[c:37](-[c:47]3[cH:48][cH:49][c:50]([C:53]4([NH2:57])[CH2:54][O:55][CH2:56]4)[cH:51][cH:52]3)[c:38](-[c:41]3[cH:42][cH:43][cH:44][cH:45][cH:46]3)[o:39][c:40]12

Participants

3

Reactant 2

HCID 510305983-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-oneHCID 670677152-Methyl-propane-2-sulfinic acid {3-[4-(8-bromo-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-oxetan-3-yl}-amide

Product 1

HCID 510300443-[4-(3-Amino-oxetan-3-yl)-phenyl]-8-bromo-2-phenyl-chromen-4-one

Sources & evidence

ORD record
ord-8b2501ad9cbe4e87bd66a6a0f762e7ce
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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