Sodium Hydroxide → HCID 66659940, compound

Participants

Reaction Steps

1.02 g (2.17 mmol) of methyl 1-(3-chloropyridin-2-yl)-3-{[4-(trifluoromethoxy)phenyl]ethynyl}-1H-pyrazole-5-carboxylate were dissolved in 20 ml of ethanol, 1.31 g (3.26 mmol) of 10% strength aqueous sodium hydroxide solution were added and the mixture was stirred at RT for 2 h. The solvent was distilled off under reduced pressure, the residue was taken up in water and the mixture was extracted once with methyl tert-butyl ether. The aqueous phase was then acidified with 2N hydrochloric acid and extracted three times with methyl tert-butyl ether. The combined organic phases were dried over sodium sulphate and concentrated.

Provenance & Evidence