N,N'-Dimethylethylenediamine → HCID 86661387, compound

Participants

Reaction Steps

600 mg (1.76 mmol) of ethyl 4-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-2-carboxylate and 527 mg (1.76 mmol) of 1-[3,5-bis(trifluoromethyl)phenyl]imidazolidin-2-one were initially charged in 30 ml of toluene, and 40.4 mg (0.21 mmol) of copper(I) iodide, 31.2 mg (0.35 mmol) of N,N′-dimethylethylenediamine and 489 mg (3.53 mmol) of potassium carbonate were added successively at room temperature. The reaction mixture was stirred under reflux for 10 h. The solvent was then distilled off, the residue was taken up in ethyl acetate and the solution was washed in each case once with water and saturated sodium chloride solution, dried over sodium sulphate and concentrated using a rotary evaporator. The desired product was isolated by chromatographic purification.

Provenance & Evidence