HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxyamine hydrochloride → methyl 1-(3-chloropyridin-2-yl)-3-[(hydroxyimino)methyl]-1H-pyrazole-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | HCID 86661390 | HCID 86661390 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | methyl 1-(3-chloropyridin-2-yl)-3-[(hydroxyimino)methyl]-1H-pyrazole-5-carboxylate | HCID 136407523 | — |
Reaction Steps
Methyl 1-(3-chloropyridin-2-yl)-3-formyl-1H-pyrazole-5-carboxylate (0.99 g), hydroxylamine hydrochloride (0.39 g) and sodium acetate (0.61 g) were stirred at RT in a mixture of 5 ml of ethanol and 3 ml of water for 30 min. The mixture was diluted with methyl tert-butyl ether, washed with saturated sodium chloride solution and dried over sodium sulphate. Distillative removal of the solvent gave the desired target product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08791139B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-82c8cfae78df4abc95c5f024c597ce50 |
| Source note | uspto-grants-2014_07 |