Acetonitrile → 2-Amino-6-([2-(4-chlorophenyl)-1,3-thiazol-4-yl]methylsulfanyl)-4-(1,3-thiazol-5-yl)pyridine-3,5-dicarbonitrile

Participants

Reaction Steps

370 mg (1.427 mmol) of 2-amino-6-sulphanyl-4-(1,3-thiazol-5-yl)pyridine-3,5-dicarbonitrile, 383 mg (1.570 mmol) of 4-(chloromethyl)-2-(4-chlorophenyl)-1,3-thiazole and 359 mg of sodium bicarbonate are stirred in 7 ml of DMF for 1 hour. 150 ml of acetonitrile and 100 ml of water are added to the reaction mixture, and the precipitated solid is filtered off and dried under high vacuum. This gives 569 mg (85% of theory) of the target compound.

Provenance & Evidence