HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 44548551, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 3-(Chloromethyl)benzoic acid | HCID 241752 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 178494293 | HCID 178494293 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 44548551 | HCID 44548551 | — |
Reaction Steps
50 mg (0.153 mmol) of the compound from Example 10A together with 29 mg (0.168 mmol) of 3-(chloromethyl)benzoic acid and 38.5 mg (0.458 mmol) of sodium bicarbonate are stirred in 0.6 ml of DMF at room temperature for 2 h. Water is added and the reaction mixture is purified by preparative HPLC (with 0.15% hydrochloric acid added).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08791146B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-29db7164ca2e4ceb9993a60586c61b65 |
| Source note | uspto-grants-2014_07 |