Sodium borohydride → HCID 58443299, compound

Participants

Reaction Steps

To a solution of methyl 5-chloro-4-(3-fluorophenyl)picolinate (0.196 g, 0.738 mmol) in MeOH (6 mL) was added NaBH4 (0.152 g, 4.02 mmol). The reaction mixture was stirred at rt for 10 min, and diluted with EtOAc and water. The aqueous phase was extracted with EtOAc (1×) and the combined organic extracts were washed with brine (1×), dried over MgSO4, filtered, and concentrated. Purification by flash column chromatography on silica gel (10% to 60% EtOAc in hexanes) gave (5-chloro-4-(3-fluorophenyl)pyridin-2-yl)methanol.

Provenance & Evidence