HCID 58443299, compound → HCID 58443273, compound

Participants

Reaction Steps

To a solution of (5-chloro-4-(3-fluorophenyl)pyridin-2-yl)methanol (0.138 g, 0.58 mmol) in dichloromethane (5 mL) at room temperature was added manganese dioxide (0.49 g, 5.6 mmol). The reaction mixture was stirred at room temperature for 3 d, filtered, and concentrated. Purification by flash column chromatography on silica gel (10% to 20% EtOAc in hexanes) gave 5-chloro-4-(3-fluorophenyl)picolinaldehyde.

Provenance & Evidence