HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(3,4,5-Trimethoxyphenylamino)-6-chloropyrazine → 6-(Pyridin-4-yloxy)-N-(3,4,5-trimethoxyphenyl)pyrazin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(3,4,5-Trimethoxyphenylamino)-6-chloropyrazine | HCID 11609049 | — |
| Reactant | HCID 178418642 | HCID 178418642 | — |
| Product | 6-(Pyridin-4-yloxy)-N-(3,4,5-trimethoxyphenyl)pyrazin-2-amine | HCID 24879394 | 50% |
Reaction Steps
Using Method X with 150 mg of 2-(3,4,5-trimethoxyphenylamino)-6-chloropyrazine and 4-hydroxypyridine, the title compound was obtained (89 mg). Yield: 50%. 1H NMR (250 MHz, DMSO-d6) δ 3.64 (s, 3H), 3.79 (s, 6H), 6.29 (d, 2H, J=7.9 Hz), 7.07 (s, 2H), 8.19 (s, 1H), 8.32 (s, 1H), 8.43 (d, 2H, J=8.0 Hz), 9.91 (bs, 1H). 13C NMR (62.9 MHz, DMSO-d6) δ 55.61, 60.11, 96.50, 117.94, 121.98, 132.71, 132.79, 135.77, 136.52, 145.43, 150.31, 152.85, 178.22. m/z 355.1 [(M+H)+ calcd for C18H18N4O4 354.1].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07737152B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-54f08182d6034e6d9bd403a29aca9e62 |
| Source note | uspto-grants-2010_06 |