Acetonitrile → 2-(4-methoxy-pyridin-3-yl)-1H-indole-3,5-dicarbonitrile

HRID 1630871Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][N:6]=[CH:5][C:4]=1[C:9]1[NH:10][C:11]2[C:16]([CH:17]=1)=[CH:15][C:14]([C:18]#[N:19])=[CH:13][CH:12]=2.[C:20](#[N:22])C>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][N:6]=[CH:5][C:4]=1[C:9]1[NH:10][C:11]2[C:16]([C:17]=1[C:20]#[N:22])=[CH:15][C:14]([C:18]#[N:19])=[CH:13][CH:12]=2

Participants

Reactant 2

HCID 6342Acetonitrile

HCID 582156342-(4-methoxy-pyridin-3-yl)-1H-indole-5-carbonitrile

Product 1

HCID 582157722-(4-methoxy-pyridin-3-yl)-1H-indole-3,5-dicarbonitrile

Procedure

2-(4-Methoxy-pyridin-3-yl)-1H-indole-5-carbonitrile (Example 128) is processed according to the method described in Example 140, using acetonitrile instead of dichloromethane, to give 2-(4-methoxy-pyridin-3-yl)-1H-indole-3,5-dicarbonitrile. MS (ESI) m/z 275.08 (M+H)+.

Sources & evidence

ORD record: ord-2fcc87c9b7c64dacae451f82e5620484
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08791141B2

Reaction notes

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