Acetonitrile → HCID 58215831, compound

HRID 1630872Notes

Reaction equation

HRID 1630872 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[NH:9][C:10]3[C:15]([CH:16]=2)=[CH:14][CH:13]=[CH:12][CH:11]=3)[CH:5]=[N:6][CH:7]=1.ClCCl.[C:20](#[N:22])C>>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[NH:9][C:10]3[C:15]([C:16]=2[C:20]#[N:22])=[CH:14][CH:13]=[CH:12][CH:11]=3)[CH:5]=[N:6][CH:7]=1

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 6344DichloromethaneHCID 58215657HCID 58215657, compound

Product 1

HCID 58215831HCID 58215831, compound

Procedure

2-(5-Fluoro-pyridin-3-yl)-1H-indole (Example 92) is processed according to the method described in Example 140, using a mixture of dichloromethane and acetonitrile instead of dichloromethane, to give 2-(5-fluoro-pyridin-3-yl)-1H-indole-3-carbonitrile. MS (ESI) m/z 238.0 (M+H)+.

Sources & evidence

ORD record
ord-f7096086846044aa80f86d42d86514ae
Source dataset
uspto-grants-2014_07
Patent number
US08791141B2

Reaction notes

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