Trifluoromethylsulfonamide → Trifluoromethanesulfonic acid [5-(3-cyano-1-methyl-1h-indol-2-yl)-pyridin-3-ylmethyl]-amide

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Reaction Steps

2-(5-Formyl-pyridin-3-yl)-1-methyl-1H-indole-3-carbonitrile (Example 127) and trifluoromethanesulfonamide are processed according to the method described in Example 170 to give trifluoromethanesulfonic acid [5-(3-cyano-1-methyl-1H-indol-2-yl)-pyridin-3-ylmethyl]amide. 1H NMR (400 MHz, DMSO-d6) δ ppm 3.79 (s, 3H), 4.58 (s, 2H), 7.34-7.39 (m, 1H), 7.42-7.47 (m, 1H), 7.72 (d, J=7.7 Hz, 1H), 7.77 (d, J=8.3 Hz, 1H), 8.10 (t, J=2.1 Hz, 1H), 8.78 (d, J=2.1 Hz, 1H), 8.85 (d, J=2.1 Hz, 1H), 10.19 (br. s, 1H). HRMS (ESI) m/z 395.0779 [(M+H)+ Calcd for C17H14F3N4O2S: 395.0790].

Provenance & Evidence