(1-Methyl-1H-indol-2-yl)boronic acid → HCID 58215774, compound

HRID 1630958Notes

Reaction equation

HRID 1630958 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH2:8][NH:9][S:10]([CH:13](S(CC)(=O)=O)[CH3:14])(=[O:12])=[O:11])[CH:5]=[N:6][CH:7]=1.[CH3:20][N:21]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:23]=[C:22]1B(O)O>>[CH2:13]([S:10]([N:9]([CH2:8][C:4]1[CH:5]=[N:6][CH:7]=[C:2]([C:22]2[N:21]([CH3:20])[C:29]3[C:24]([CH:23]=2)=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH:3]=1)[S:10]([CH2:13][CH3:14])(=[O:11])=[O:12])(=[O:12])=[O:11])[CH3:14]

Participants

3

Reactant 2

HCID 22733820(1-Methyl-1H-indol-2-yl)boronic acidHCID 86646467HCID 86646467, compound

Product 1

HCID 58215774HCID 58215774, compound

Procedure

N-((5-Bromopyridin-3-yl)methyl)-1-(ethylsulfonyl)ethanesulfonamide and N-methyl-indole-2-boronic acid are processed according to the procedure described in Example 100 to give N-(ethylsulfonyl)-N-((5-(1-methyl-1H-indol-2-yl)pyridin-3-yl)methyl)ethanesulfonamide. MS (ESI) m/z 422.0 (M+H)+.

Sources & evidence

ORD record
ord-165236e3b4ff4d88a0e9d8f37ff728a6
Source dataset
uspto-grants-2014_07
Patent number
US08791141B2

Reaction notes

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