Dimethylformamide → 2-(Methoxymethyl)-2'-methylbiphenyl-4-carbonyl chloride

Participants

Reaction Steps

Oxalyl chloride (2.0 mL, 23.6 mmol) and anhydrous DMF (0.060 mL, 0.78 mmol) were added into a solution of 2-(methoxymethyl)-2′-methylbiphenyl-4-carboxylic acid (2.0 g, 7.8 mmol) in anhydrous DCM (40 mL). After 15 hours at RT, the reaction mixture was concentrated under reduced pressure to give the title compound as a yellow oil (2.1 g, quantitative), which was used without further purification.

Provenance & Evidence