1-Naphthalenethiol → HCID 24879395, compound

Participants

Reaction Steps

Using Method X with 150 mg of 2-(3,4,5-trimethoxyphenylamino)-6-chloropyrazine and 1-thionaphthol, the title compound was obtained (68 mg). Yield: 32%. 1H NMR (250 MHz, DMSO-d6) δ 3.60 (s, 3H), 3.61 (s, 6H), 6.94 (s, 2H), 7.25 (s, 1H), 7.57-7.63 (m, 3H), 7.91 (s, 1H), 7.95 (dd, 1H, J1=1.2 Hz, J2=7.1 Hz), 8.03-8.07 (m, 1H), 8.11 (d, 1H, J=8.3 Hz), 8.26-8.30 (m, 1H), 9.54 (s, 1H). 13C NMR (62.9 MHz, DMSO-d6) δ 55.55, 60.09, 96.41, 124.82, 126.23, 126.58, 126.74, 127.65, 128.90, 129.90, 130.63, 131.09, 132.52, 133.33, 133.97, 134.60, 136.13, 151.27, 152.55, 152.74. m/z 420.1 [(M+H)+ calcd for C23H21N3O3S 419.1].

Provenance & Evidence