HCID 54065546, compound → HCID 46908900, compound

HRID 1631018Notes

Reaction equation

HRID 1631018 reaction equation
Br[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=O)=[CH:4][C:3]=1[CH2:12][O:13]C.[Cl:15][C:16]1[CH:17]=[C:18]([C:23](=[N:25]O)[NH2:24])[CH:19]=[N:20][C:21]=1[Cl:22]>>[Cl:22][C:21]1[C:16]([Cl:15])=[CH:17][C:18]([C:23]2[N:25]=[C:12]([C:3]3[CH:2]=[CH:11][C:10]([C:2]4[CH:11]=[CH:10][CH:5]=[CH:4][C:3]=4[CH3:12])=[C:5]([CH2:6][O:8][CH3:9])[CH:4]=3)[O:13][N:24]=2)=[CH:19][N:20]=1

Participants

3

Reactant 2

HCID 54065546HCID 54065546, compoundHCID 58554220Methyl 4-bromo-3-(methoxymethyl)benzoate

Product 1

HCID 46908900HCID 46908900, compound

Procedure

The title compound was prepared following procedure described in Method B starting from Intermediate A1 and 5,6-dichloro-N′-hydroxypyridine-3-carboximidamide (WO2000015637). The title compound was obtained as a white powder. HPLC (Method A), Rt: 6.7 min (purity: 95.0%). UPLC/MS, M+(ESI): 426.1. 1H NMR (DMSO-d6, 300 MHz) δ 9.08 (d, J=2.1 Hz, 1H), 8.72 (d, J=2.1 Hz, 1H), 8.34 (d, J=1.8 Hz, 1H), 8.19 (dd, J=7.9, 1.8 Hz, 1H), 7.44 (d, J=7.9 Hz, 1H), 7.36 (m, 2H), 7.30 (m, 1H), 7.15 (d, J=7.1 Hz, 1H), 4.23 (d, J=12.7 Hz, 1H), 4.16 (d, J=12.7 Hz, 1H), 3.25 (s, 3H), 2.03 (s, 3H).

Workup

  1. customThe title compound was prepared following procedure

Sources & evidence

ORD record
ord-9c4e6cd585d447a7839c68cf4c034942
Source dataset
uspto-grants-2014_07
Patent number
US08791142B2

Reaction notes

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