Hydroxylamine → HCID 136359924, compound

Participants

Reaction Steps

A solution of 2-(hydroxymethyl)isonicotinonitrile (ChemPacific, 0.496 g; 3.7 mmol) and 50% aqueous hydroxylamine (1.2 mL) in ethanol (4.8 mL) was heated at 75° C. for 18 hours. The solvent was evaporated in vacuo. The residue was partitioned between DCM and water. The organic phase was poured through a hydrophobic frit and evaporated in vacuo to afford the title compound. 1H NMR (400 MHz, DMSO-d6) δ 10.02 (1 H, s), 8.50 (1 H, d, J=5.2 Hz), 7.80 (1 H, s), 7.52 (1 H, dd, J=5.2, 1.7 Hz), 5.99 (2 H, br s), 5.45 (1 H, t, J=5.8 Hz), 4.60 (2 H, d, J=5.8 Hz).

Provenance & Evidence