Potassium Carbonate → HCID 86660280, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-bromomethylnicotinonitrile (Advanced Chemical Intermediates, 1.39 g; 7.06 mmol), sarcosine tert-butyl ester hydrochloride (1.54 g; 8.47 mmol) and K2CO3 (2.34 g; 17.0 mmol) in MeCN (25 mL) heated at 60° C. for 18 hours. The solvent was evaporated in vacuo. The residue was dissolved in a mixture of DCM and water and then poured through a hydrophobic frit. The filtrate was evaporated to afford the title product (2.17 g, quantitative). 1H NMR (CDCl3, 400 MHz) δ 8.82 (1 H, d, J=2 Hz), 7.95-7.92 (1 H, dd, J=8.4, 2 Hz), 7.73 (1 H, d, J=8 Hz), 3.91 (2 H, s), 3.28 (2 H, s), 2.41 (3 H, s), 1.48 (9 H, s).

Provenance & Evidence