Acetic Acid → {2-Amino-6-[2-(tert-butylaminomethyl)-5-fluorophenyl]quinazolin-4-yl}-(1,3-dihydroisoindol-2-yl)methanone

Participants

Reaction Conditions

Reaction Steps

150 mg of 2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4-fluorobenzaldehyde are dissolved in 2 ml of 1,2-dichloroethane and 2 ml of tetrahydrofuran. 53 μl of tert-butylamine and 40 μl of glacial acetic acid are added, and the mixture is stirred at 60° C. for 6 h. After cooling to 25° C., 161 mg of sodium triacetoxyborohydride are added and stirred at 25° C. for a further 12 h. The mixture is poured into water, extracted three times with dichloromethane, and the combined organic phases are dried over sodium sulfate. After filtration, the filtrate is evaporated to dryness and purified by chromatography (reversed phase HPLC).

Provenance & Evidence