HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1631159Generated: November 4, 2026
Thionyl Chloride → [2-Amino-6-(2-chloromethyl-5-fluorophenyl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone
https://huagongshe.com/reaction/1631159
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | [2-Amino-6-[5-fluoro-2-(hydroxymethyl)phenyl]quinazolin-4-yl]isoindolin-2-ylmethanone | HCID 56943415 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | [2-Amino-6-(2-chloromethyl-5-fluorophenyl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone | HCID 66837686 | — |
Reaction Steps
218 μl of thionyl chloride are added dropwise to 622 mg of [2-amino-6-(2-hydroxymethyl-5-fluorophenyl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone in 50 ml of dichloromethane, and the mixture is stirred at 25° C. for 2 h. The mixture is evaporated to dryness in vacuo, the residue is taken up in 10 ml of toluene, and the operation is repeated. The residue is employed in the subsequent reactions without further treatment.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08791129B2 |
|---|
| Source dataset | uspto-grants-2014_07 |
|---|
| ORD ID | ord-dd4344220068427989e255daebe52c94 |
|---|
| Source note | uspto-grants-2014_07 |
|---|
