HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1631173Generated: November 3, 2026
Methanol → 2-[2-Amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl dimethylcarbamate
https://huagongshe.com/reaction/1631173
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Dimethylcarbamoyl Chloride | HCID 6598 | — |
| Reactant | [2-Amino-6-[4,5-difluoro-2-(hydroxymethyl)phenyl]quinazolin-4-yl]isoindolin-2-ylmethanone | HCID 56943446 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-[2-Amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl dimethylcarbamate | HCID 68078098 | — |
Reaction Steps
20 μl of dimethylcarbamoyl chloride are added to a solution of 100 mg of [2-amino-6-(4,5-difluoro-2-hydroxymethylphenyl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone and 2 mg of 4-(dimethylamino)pyridine (DMAP) in 5 ml of dimethylformamide (DMF), and the mixture is heated at 80° C. for 18 h. After 18 h, 10 ml of methanol are added, the mixture is evaporated to dryness in vacuo and purified by normal-phase chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08791129B2 |
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| Source dataset | uspto-grants-2014_07 |
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| ORD ID | ord-e2baf418843844ed816e55496f1e3aaf |
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| Source note | uspto-grants-2014_07 |
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