反应详情

温度

25 °C

50 ml of thionyl chloride are added to 2 g of [2-amino-6-(4,5-difluoro-2-hydroxymethylphenyl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone, and the mixture is stirred at 25° C. for 1 h. The mixture is subsequently evaporated to dryness in vacuo, the residue is taken up a further twice with 50 ml of dichloromethane each time, and the mixture is again evaporated to dryness in vacuo.

1. customThe mixture is subsequently evaporated to dryness in vacuo
2. customthe mixture is again evaporated to dryness in vacuo