HCID 66692883, compound → HCID 178523808, compound

HRID 1631320Notes

Reaction equation

HRID 1631320 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C@H:8]2[CH2:12][CH2:11][CH2:10][N:9]2[C:13]2[CH:18]=[CH:17][N:16]3[N:19]=[CH:20][C:21]([C:22]([OH:24])=O)=[C:15]3[N:14]=2)[CH:5]=[CH:6][CH:7]=1.[NH2:25][C@H:26]1[CH2:31][CH2:30][C@H:29]([OH:32])[CH2:28][CH2:27]1>>[F:1][C:2]1[CH:3]=[C:4]([C@H:8]2[CH2:12][CH2:11][CH2:10][N:9]2[C:13]2[CH:18]=[CH:17][N:16]3[N:19]=[CH:20][C:21]([C:22]([NH:25][C@H:26]4[CH2:31][CH2:30][C@H:29]([OH:32])[CH2:28][CH2:27]4)=[O:24])=[C:15]3[N:14]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 66692883HCID 66692883, compoundHCID 178511715HCID 178511715, compound

Product 1

HCID 178523808HCID 178523808, compoundYield 62%

Procedure

Prepared by the method as described in Example 1 using (R)-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (Preparation E) and (trans)-4-aminocyclohexanol to yield the title compound as a white solid (31 mg, 62% yield). MS (apci) m/z=424.1 (M+H).

Workup

  1. customPrepared by the method

Sources & evidence

ORD record
ord-a5b19f37f2f843cd94c2b05e80c34f4e
Source dataset
uspto-grants-2014_07
Patent number
US08791123B2

Reaction notes

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