Cyclopropylamine → HCID 67501723, compound

HRID 1631321Notes

Reaction equation

HRID 1631321 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C@H:8]2[CH2:12][CH2:11][CH2:10][N:9]2[C:13]2[CH:18]=[CH:17][N:16]3[N:19]=[CH:20][C:21]([C:22]([OH:24])=O)=[C:15]3[N:14]=2)[CH:5]=[CH:6][CH:7]=1.[CH:25]1([NH2:28])[CH2:27][CH2:26]1>>[CH:25]1([NH:28][C:22]([C:21]2[CH:20]=[N:19][N:16]3[CH:17]=[CH:18][C:13]([N:9]4[CH2:10][CH2:11][CH2:12][C@@H:8]4[C:4]4[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=4)=[N:14][C:15]=23)=[O:24])[CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 66692883HCID 66692883, compound

Product 1

HCID 67501723HCID 67501723, compoundYield 54%

Procedure

Prepared by the method as described in Example 1 using (R)-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (Preparation E) and cyclopropylamine to yield the title compound as a white solid (23 mg, 54% yield). MS (apci) m/z=366.1 (M+H).

Workup

  1. customPrepared by the method

Sources & evidence

ORD record
ord-cd03a44c724b4c3683c90ef3677c8a3d
Source dataset
uspto-grants-2014_07
Patent number
US08791123B2

Reaction notes

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