Cyclopropylamine → HCID 67501573, compound

HRID 1631325Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([C@H:8]2[CH2:12][C@@H:11]([OH:13])[CH2:10][N:9]2[C:14]2[CH:19]=[CH:18][N:17]3[N:20]=[CH:21][C:22]([C:23](O)=[O:24])=[C:16]3[N:15]=2)[CH:5]=[CH:6][CH:7]=1.[CH:26]1([NH2:29])[CH2:28][CH2:27]1>>[CH:26]1([NH:29][C:23]([C:22]2[CH:21]=[N:20][N:17]3[CH:18]=[CH:19][C:14]([N:9]4[CH2:10][C@H:11]([OH:13])[CH2:12][C@@H:8]4[C:4]4[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=4)=[N:15][C:16]=23)=[O:24])[CH2:28][CH2:27]1

Participants

Reactant 2

HCID 69828Cyclopropylamine

HCID 66847779HCID 66847779, compound

Product 1

HCID 67501573HCID 67501573, compoundYield 66%

Procedure

Prepared by the method described in Example 1 using 5-((2R,4R)-2-(3-fluorophenyl)-4-hydroxypyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid and substituting tert-butyl amine with cyclopropylamine to provide the final product as a white solid (15 mg, 66% yield). MS (apci) m/z=382.1 (M+H).

Workup

customPrepared by the method

Sources & evidence

ORD record: ord-1971adc9d4b04474942f1d7207930429
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08791123B2

Reaction notes

Loading…