2-Propanol, 1-amino-2-methyl- → (R)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)-N-(2-hydroxy-2-methylpropyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

HRID 1631329Notes

Reaction equation

HRID 1631329 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:25][CH3:26])=[C:6]([C@H:8]2[CH2:12][CH2:11][CH2:10][N:9]2[C:13]2[CH:18]=[CH:17][N:16]3[N:19]=[CH:20][C:21]([C:22]([OH:24])=O)=[C:15]3[N:14]=2)[CH:7]=1.[NH2:27][CH2:28][C:29]([CH3:32])([OH:31])[CH3:30]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:25][CH3:26])=[C:6]([C@H:8]2[CH2:12][CH2:11][CH2:10][N:9]2[C:13]2[CH:18]=[CH:17][N:16]3[N:19]=[CH:20][C:21]([C:22]([NH:27][CH2:28][C:29]([OH:31])([CH3:32])[CH3:30])=[O:24])=[C:15]3[N:14]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 951022-Propanol, 1-amino-2-methyl-HCID 66847828HCID 66847828, compound

Product 1

HCID 67500799(R)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)-N-(2-hydroxy-2-methylpropyl)pyrazolo[1,5-a]pyrimidine-3-carboxamideYield 55%

Procedure

Prepared by the method described in Example 1 using (R)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (Preparation G) and 1-amino-2-methylpropan-2-ol to yield the title compound as a white solid (17 mg, 55% yield). MS (apci) m/z=428.1 (M+H).

Workup

  1. customPrepared by the method

Sources & evidence

ORD record
ord-072ed96d05754c8ab6e8b015a45d20c1
Source dataset
uspto-grants-2014_07
Patent number
US08791123B2

Reaction notes

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