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HRID1631335

反应详情

EQUATION

反应方程式

HRID 1631335 的结构方程式

REACTANTS

反应物

2
结构：NC[C@H](O)CO
HCID440902

(S)-3-Amino-1,2-propanediol

C3H9NO2

结构：COc1ccc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)O)c2n1
HCID66847828

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC[C@H](O)CO)c2n1
HCID66852375

未命名化合物

收率 53%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O.CO
溶剂HCID21584119

未命名化合物

PROCEDURE

实验过程

Prepared by the method of Example 1, using (R)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (Preparation G) and (S)-3-aminopropane-1,2-diol (2.0 equiv). The crude material was purified by SiO2 column chromatography, eluting with EtOAc then 10% MeOH-EtOAc to afford the title compound as a white solid (53% yield). MS (apci) m/z=430.1 (M+H).

WORKUP

后处理

  1. customPrepared by the method of Example 1
  2. customThe crude material was purified by SiO2 column chromatography
  3. washeluting with EtOAc