Ammonium Chloride → HCID 67501751, compound

HRID 1631343Notes

Reaction equation

HRID 1631343 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:25]([F:28])([F:27])[F:26])=[C:6]([C@H:8]2[CH2:12][CH2:11][CH2:10][N:9]2[C:13]2[CH:18]=[CH:17][N:16]3[N:19]=[CH:20][C:21]([C:22](O)=[O:23])=[C:15]3[N:14]=2)[CH:7]=1.[Cl-].[NH4+:30]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:25]([F:27])([F:28])[F:26])=[C:6]([C@H:8]2[CH2:12][CH2:11][CH2:10][N:9]2[C:13]2[CH:18]=[CH:17][N:16]3[N:19]=[CH:20][C:21]([C:22]([NH2:30])=[O:23])=[C:15]3[N:14]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 25517Ammonium ChlorideHCID 66848061HCID 66848061, compound

Product 1

HCID 67501751HCID 67501751, compoundYield 78%

Procedure

Prepared by the method described in Example 1 using (R)-5-(2-(5-fluoro-2-(trifluoromethyl)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (Preparation M) and ammonium chloride. The crude material was purified by reverse phase HPLC (0-60% acetonitrile/water) to yield the title compound (23 mg, 78% yield). MS (apci) m/z=394.0 (M+H).

Workup

  1. customPrepared by the method
  2. customThe crude material was purified by reverse phase HPLC (0-60% acetonitrile/water)

Sources & evidence

ORD record
ord-27bb17dc974b4f3f851ca0d34d007324
Source dataset
uspto-grants-2014_07
Patent number
US08791123B2

Reaction notes

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