2-Amino-2-methylpropionitrile → HCID 67502485, compound

HRID 1631348Notes

Reaction equation

HRID 1631348 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C@H:8]2[CH2:12][CH2:11][CH2:10][N:9]2[C:13]2[CH:18]=[CH:17][N:16]3[N:19]=[CH:20][C:21]([C:22](O)=[O:23])=[C:15]3[N:14]=2)[CH:5]=[N:6][CH:7]=1.[NH2:25][C:26]([CH3:30])([CH3:29])[C:27]#[N:28]>>[C:27]([C:26]([NH:25][C:22]([C:21]1[CH:20]=[N:19][N:16]2[CH:17]=[CH:18][C:13]([N:9]3[CH2:10][CH2:11][CH2:12][C@@H:8]3[C:4]3[CH:5]=[N:6][CH:7]=[C:2]([F:1])[CH:3]=3)=[N:14][C:15]=12)=[O:23])([CH3:30])[CH3:29])#[N:28]

Participants

3

Reactant 2

HCID 880222-Amino-2-methylpropionitrileHCID 66847898HCID 66847898, compound

Product 1

HCID 67502485HCID 67502485, compoundYield 57%

Procedure

Prepared by the method described in Example 1 using (R)-5-(2-(5-fluoropyridin-3-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (Preparation I) and 2-amino-2-methylpropanenitrile to yield the title compound as a white solid (21 mg, 57% yield). MS (apci) m/z=394.1 (M+H).

Workup

  1. customPrepared by the method

Sources & evidence

ORD record
ord-fe3c9ded207844568b52d18d84f41ff4
Source dataset
uspto-grants-2014_07
Patent number
US08791123B2

Reaction notes

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