O-Methylhydroxylamine → HCID 86664572, compound

HRID 1631352Notes

Reaction equation

HRID 1631352 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C@H:8]2[CH2:12][CH2:11][CH2:10][N:9]2[C:13]2[CH:18]=[CH:17][N:16]3[N:19]=[CH:20][C:21]([C:22]([OH:24])=O)=[C:15]3[N:14]=2)[CH:5]=[N:6][CH:7]=1.[CH3:25][O:26][NH2:27]>>[F:1][C:2]1[CH:3]=[C:4]([C@H:8]2[CH2:12][CH2:11][CH2:10][N:9]2[C:13]2[CH:18]=[CH:17][N:16]3[N:19]=[CH:20][C:21]([C:22]([NH:27][O:26][CH3:25])=[O:24])=[C:15]3[N:14]=2)[CH:5]=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 4113O-MethylhydroxylamineHCID 66847898HCID 66847898, compound

Product 1

HCID 86664572HCID 86664572, compoundYield 35%

Procedure

Prepared by the method as described in Example 1 using (R)-5-(2-(5-fluoropyridin-3-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (Preparation I) and O-methylhydroxylamine to yield the title compound as a white solid (15 mg, 35% yield). MS (apci) m/z=357.0 (M+H).

Workup

  1. customPrepared by the method

Sources & evidence

ORD record
ord-c5efb20feda0430ebc3464e8b8db5f24
Source dataset
uspto-grants-2014_07
Patent number
US08791123B2

Reaction notes

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