Cyclopropylamine → HCID 67501650, compound

HRID 1631359Notes

Reaction equation

HRID 1631359 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C@H:13]2[CH2:17][CH2:16][CH2:15][N:14]2[C:18]2[CH:23]=[CH:22][N:21]3[N:24]=[CH:25][C:26]([C:27]([OH:29])=O)=[C:20]3[N:19]=2)[CH:5]=[C:6]([O:8][CH2:9][CH2:10][O:11][CH3:12])[CH:7]=1.[CH:30]1([NH2:33])[CH2:32][CH2:31]1>>[CH:30]1([NH:33][C:27]([C:26]2[CH:25]=[N:24][N:21]3[CH:22]=[CH:23][C:18]([N:14]4[CH2:15][CH2:16][CH2:17][C@@H:13]4[C:4]4[CH:5]=[C:6]([O:8][CH2:9][CH2:10][O:11][CH3:12])[CH:7]=[C:2]([F:1])[CH:3]=4)=[N:19][C:20]=23)=[O:29])[CH2:32][CH2:31]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 66847804HCID 66847804, compound

Product 1

HCID 67501650HCID 67501650, compoundYield 52%

Procedure

Prepared by the method described in Example 1 using (R)-5-(2-(3-fluoro-5-(2-methoxyethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid and cyclopropylamine to yield the title compound as a white solid (16 mg, 52% yield). MS (apci) m/z=440.1 (M+H).

Workup

  1. customPrepared by the method

Sources & evidence

ORD record
ord-b7405568a2dd48ebb8e2b5433cd7b45e
Source dataset
uspto-grants-2014_07
Patent number
US08791123B2

Reaction notes

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