HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 67501506, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | HCID 66847769 | HCID 66847769 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 67501506 | HCID 67501506 | 38% |
Reaction Steps
Prepared by the method described in Example 1 using (R)-5-(2-(5-fluoro-2-methoxypyridin-3-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (Preparation K) and 7N NH3 in MeOH. The combined organic extracts were concentrated and the residue was purified by reverse phase HPLC (0-80% acetonitrile/water) to provide the title compound (15 mg, 38% yield). MS (apci) m/z=357.0 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08791123B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-ae28fd6311d34c998514c3b6908f05bf |
| Source note | uspto-grants-2014_07 |