Ammonium Chloride → HCID 67500391, compound

HRID 1631364Notes

Reaction equation

HRID 1631364 reaction equation
Cl.[F:2][C:3]1[CH:4]=[CH:5][C:6]([O:26][CH2:27][CH2:28][N:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)=[C:7]([C@H:9]2[CH2:13][CH2:12][CH2:11][N:10]2[C:14]2[CH:19]=[CH:18][N:17]3[N:20]=[CH:21][C:22]([C:23](O)=[O:24])=[C:16]3[N:15]=2)[CH:8]=1.[Cl-].[NH4+:36]>>[F:2][C:3]1[CH:4]=[CH:5][C:6]([O:26][CH2:27][CH2:28][N:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)=[C:7]([C@H:9]2[CH2:13][CH2:12][CH2:11][N:10]2[C:14]2[CH:19]=[CH:18][N:17]3[N:20]=[CH:21][C:22]([C:23]([NH2:36])=[O:24])=[C:16]3[N:15]=2)[CH:8]=1

Participants

3

Reactant 2

HCID 25517Ammonium ChlorideHCID 66848039HCID 66848039, compound

Product 1

HCID 67500391HCID 67500391, compoundYield 91%

Procedure

Prepared by the method described in Example 76, Step F, using ((R)-5-(2-(5-fluoro-2-(2-morpholinoethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid hydrochloride and ammonium chloride to yield the title compound as a white solid (42.2 mg, 91% yield). MS (apci) m/z=455.1 (M+H).

Workup

  1. customPrepared by the method

Sources & evidence

ORD record
ord-74325232dcf744fab1d4a4d12df8d329
Source dataset
uspto-grants-2014_07
Patent number
US08791123B2

Reaction notes

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