Cyclopropylamine → HCID 67500657, compound

HRID 1631365Notes

Reaction equation

HRID 1631365 reaction equation
Cl.[F:2][C:3]1[CH:4]=[CH:5][C:6]([O:26][CH2:27][CH2:28][N:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)=[C:7]([C@H:9]2[CH2:13][CH2:12][CH2:11][N:10]2[C:14]2[CH:19]=[CH:18][N:17]3[N:20]=[CH:21][C:22]([C:23]([OH:25])=O)=[C:16]3[N:15]=2)[CH:8]=1.[CH:35]1([NH2:38])[CH2:37][CH2:36]1>>[CH:35]1([NH:38][C:23]([C:22]2[CH:21]=[N:20][N:17]3[CH:18]=[CH:19][C:14]([N:10]4[CH2:11][CH2:12][CH2:13][C@@H:9]4[C:7]4[CH:8]=[C:3]([F:2])[CH:4]=[CH:5][C:6]=4[O:26][CH2:27][CH2:28][N:29]4[CH2:34][CH2:33][O:32][CH2:31][CH2:30]4)=[N:15][C:16]=23)=[O:25])[CH2:37][CH2:36]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 66848039HCID 66848039, compound

Product 1

HCID 67500657HCID 67500657, compoundYield 70%

Procedure

Prepared by the method described in Example 76, Step F using ((R)-5-(2-(5-fluoro-2-(2-morpholinoethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid hydrochloride and cyclopropylamine to yield the title compound as a white solid (35.4 mg, 70% yield). MS (apci) m/z=495.1 (M+H).

Workup

  1. customPrepared by the method

Sources & evidence

ORD record
ord-bd7c8acc92df40b8a6e1edea2ef3eaf0
Source dataset
uspto-grants-2014_07
Patent number
US08791123B2

Reaction notes

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