Trifluoroacetic acid methylene chloride → 3-Methoxyazetidine 2,2,2-trifluoroacetate

HRID 1631375Notes

Reaction equation

HRID 1631375 reaction equation
[CH3:1][O:2][CH:3]1[CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.[C:14]([OH:20])([C:16]([F:19])([F:18])[F:17])=[O:15].C(Cl)Cl>>[F:17][C:16]([F:19])([F:18])[C:14]([OH:20])=[O:15].[CH3:1][O:2][CH:3]1[CH2:6][NH:5][CH2:4]1

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 22243050tert-Butyl 3-methoxyazetidine-1-carboxylate

Product 1

HCID 668477743-Methoxyazetidine 2,2,2-trifluoroacetate

Procedure

A solution of tert-butyl 3-methoxyazetidine-1-carboxylate (270 mg, 1.44 mmol) in 1:1 TFA/DCM (1 mL) was stirred at ambient temperature for 1 hour and concentrated. The crude product was directly used in the next step assuming quantitative yield.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-5631f0ad3b744cc18f519abfe3b71890
Source dataset
uspto-grants-2014_07
Patent number
US08791123B2

Reaction notes

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