Cyclopropylamine → HCID 66854569, compound

HRID 1631389Notes

Reaction equation

HRID 1631389 reaction equation
[CH3:1][C:2]1([CH3:33])[O:6][CH:5]([CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=2[C@H:16]2[CH2:20][CH2:19][CH2:18][N:17]2[C:21]2[CH:26]=[CH:25][N:24]3[N:27]=[CH:28][C:29]([C:30]([OH:32])=O)=[C:23]3[N:22]=2)[CH2:4][O:3]1.[CH:34]1([NH2:37])[CH2:36][CH2:35]1>>[CH:34]1([NH:37][C:30]([C:29]2[CH:28]=[N:27][N:24]3[CH:25]=[CH:26][C:21]([N:17]4[CH2:18][CH2:19][CH2:20][C@@H:16]4[C:10]4[CH:11]=[C:12]([F:15])[CH:13]=[CH:14][C:9]=4[O:8][CH2:7][CH:5]4[CH2:4][O:3][C:2]([CH3:33])([CH3:1])[O:6]4)=[N:22][C:23]=23)=[O:32])[CH2:36][CH2:35]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 66852430HCID 66852430, compound

Product 1

HCID 66854569HCID 66854569, compoundYield 99%

Procedure

Prepared according to the method of Example 86, Step F, using 5-((2R)-2-(2-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid and cyclopropyl amine to yield the title compound as a white solid (33.0 mg, 99% yield). MS (apci) m/z=496.1 (M+H).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-506e535c2daf4070835ef781c2b687bc
Source dataset
uspto-grants-2014_07
Patent number
US08791123B2

Reaction notes

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