Isopropylamine → HCID 67500356, compound

HRID 1631399Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([C@H:8]2[CH2:12][C@H:11]([OH:13])[CH2:10][N:9]2[C:14]2[CH:19]=[CH:18][N:17]3[N:20]=[CH:21][C:22]([C:23](O)=[O:24])=[C:16]3[N:15]=2)[CH:5]=[CH:6][CH:7]=1.[CH:26]([NH2:29])([CH3:28])[CH3:27]>>[F:1][C:2]1[CH:3]=[C:4]([C@H:8]2[CH2:12][C@H:11]([OH:13])[CH2:10][N:9]2[C:14]2[CH:19]=[CH:18][N:17]3[N:20]=[CH:21][C:22]([C:23]([NH:29][CH:26]([CH3:28])[CH3:27])=[O:24])=[C:16]3[N:15]=2)[CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 6363Isopropylamine

HCID 66847936HCID 66847936, compound

Product 1

HCID 67500356HCID 67500356, compound

Procedure

Prepared according to the method of Example 212, Step F, using 5-((2R,4S)-2-(3-fluorophenyl)-4-hydroxypyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (Example 216, Step B) and isopropyl amine. The title compound was obtained as a white solid (5.5 mg, 49% yield). MS (apci) m/z=384.1 (M+H).

Workup

customPrepared

Sources & evidence

ORD record: ord-184f9b72169c4026862b9bb98493504d
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08791123B2

Reaction notes

Loading…