HCID 68230499, compound → HCID 53472543, compound

Participants

Reaction Steps

20 was prepared from 19 (40 mg, 0.097 mmol) by the general method shown for 15D. 20.2TFA (10 mg, 19% yield) was obtained as a sticky, off-white solid. HPLC: 0.83 min (YMC S5 ODS, 4.5×50 mm. 4 mL/min, 10-90% methanol-water 0.2% H3PO4, gradient over 12 min). MS (ES): m/z=312 [M+H]+. 1H NMR (400 MHz, DMSO-d6+MeOH-d4) δ ppm 8.81 (d, 2H, J=6.8 Hz); 8.41 (d, 2H, J=6.5 Hz); 8.18 (s, 1H); 8.09 (s, 1H); 3.39 (t, 2H, J=6.5 Hz); 2.87 (t, 2H, J=7.7 Hz); 1.80-1.89 (m, 2H).

Provenance & Evidence